M Isabel Lucena Selected Research

Chemical and Drug Induced Liver Injury

1/2022	Setting up criteria for drug-induced autoimmune-like hepatitis through a systematic analysis of published reports.
1/2022	A revised electronic version of RUCAM for the diagnosis of DILI.
1/2022	N-Acetylcysteine for the Management of Non-Acetaminophen Drug-Induced Liver Injury in Adults: A Systematic Review.
12/2021	Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction.
10/2021	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].
3/2021	Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice.
1/2021	Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
1/2021	Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.
1/2021	Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach.
10/2020	Drug induced liver injury: an update.

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M Isabel Lucena Research Topics

Disease

33	Chemical and Drug Induced Liver Injury 01/2022 - 08/2006
18	Acute Liver Failure (Fulminant Hepatic Failure) 01/2022 - 05/2003
9	Liver Diseases (Liver Disease) 01/2021 - 09/2002
5	Hepatitis 01/2022 - 02/2002
4	Cholestasis 10/2020 - 08/2002
4	Jaundice (Icterus) 01/2018 - 08/2002
4	Drug-Related Side Effects and Adverse Reactions 05/2013 - 09/2002
3	Autoimmune Hepatitis 01/2022 - 01/2016
2	Cicatrix (Scar) 11/2021 - 11/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 03/2021 - 01/2019
2	Hypersensitivity (Allergy) 11/2019 - 01/2018
2	Neoplasms (Cancer) 01/2019 - 01/2016
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2018 - 07/2011
2	Agranulocytosis (Granulocytopenia) 01/2018 - 01/2016
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 05/2003
2	Fatty Liver 01/2017 - 01/2017
2	Autoimmune Diseases (Autoimmune Disease) 01/2016 - 11/2012
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Thrombosis (Thrombus) 01/2022
1	Liver Failure 01/2022
1	Infections 01/2021
1	Necrosis 10/2020
1	Stevens-Johnson Syndrome (Lyell's Syndrome) 11/2019
1	Heart Diseases (Heart Disease) 01/2019
1	Tuberculosis (Tuberculoses) 01/2017
1	Hyperammonemia 01/2017
1	Mania (Manias) 10/2016
1	Weight Gain 10/2016
1	Schizophrenia (Dementia Praecox) 10/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2016
1	Non-alcoholic Fatty Liver Disease 10/2016
1	Psychotic Disorders (Schizoaffective Disorder) 10/2016
1	Hyperthyroidism 01/2016
1	Hypertension (High Blood Pressure) 11/2013
1	Hyperlipidemias (Hyperlipidemia) 11/2013
1	Diabetes Mellitus 11/2013

Drug/Important Bio-Agent (IBA)

28	Pharmaceutical PreparationsIBA 01/2022 - 05/2003
6	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2022 - 01/2005
5	Biomarkers (Surrogate Marker)IBA 03/2021 - 09/2011
3	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022 - 01/2019
3	XenobioticsIBA 01/2022 - 05/2016
2	Transaminases (Aminotransferases)IBA 01/2021 - 10/2016
2	Immune Checkpoint InhibitorsIBA 10/2020 - 01/2019
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2019 - 01/2018
2	HLA-B Antigens (HLA-B)IBA 01/2018 - 01/2016
2	BilirubinIBA 03/2008 - 08/2005
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2006 - 01/2006
1	VaccinesIBA 01/2022
1	Infliximab (Remicade)FDA Link 01/2022
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2022
1	Dyphylline (Diprophylline)FDA Link 01/2022
1	Methyldopa (Aldomet)FDA LinkGeneric 01/2022
1	Minocycline (Cyclops)FDA LinkGeneric 01/2022
1	Nitrofurantoin (Macrodantin)FDA LinkGeneric 01/2022
1	Nonprescription Drugs (Patent Medicines)IBA 12/2021
1	Nevirapine (Viramune)FDA Link 11/2021
1	Allopurinol (Remid)FDA LinkGeneric 11/2021
1	SulfonamidesIBA 11/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2021
1	Proteins (Proteins, Gene)FDA Link 03/2021
1	DNA (Deoxyribonucleic Acid)IBA 03/2021
1	GTP-Binding Proteins (G-Protein)IBA 03/2021
1	Isoniazid (Ftivazide)FDA LinkGeneric 01/2021
1	Illicit Drugs (Recreational Drugs)IBA 10/2020
1	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 10/2020
1	HLA-B57 antigenIBA 11/2019
1	Carbamazepine (Tegretol)FDA LinkGeneric 11/2019
1	HLA-A31 antigenIBA 11/2019
1	Floxacillin (Flucloxacillin)IBA 01/2019
1	CholesterolIBA 01/2019
1	Glutathione (Reduced Glutathione)IBA 01/2019
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2018
1	Alanine Transaminase (SGPT)IBA 01/2018
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2018
1	Anabolic Androgenic SteroidsIBA 01/2018
1	AmmoniaIBA 01/2017
1	Peroxisome ProliferatorsIBA 01/2017
1	Chlorpromazine (Thorazine)FDA Link 10/2016
1	Antipsychotic Agents (Antipsychotics)IBA 10/2016
1	antiarrhythmic peptide (AAP)IBA 10/2016
1	Methimazole (Thiamazole)FDA LinkGeneric 01/2016
1	AntigensIBA 01/2016
1	KIR ReceptorsIBA 01/2016
1	Propylthiouracil FDA Link 01/2016
1	HLA-DRB1 Chains (HLA DRB1)IBA 01/2016
1	ORALIT (ORS)IBA 01/2016
1	Antithyroid Agents (Antithyroid Drugs)IBA 01/2016
1	AutoantibodiesIBA 01/2016
1	CarbimazoleIBA 01/2016
1	Atorvastatin (Lipitor)FDA Link 03/2015
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2014
1	LipidsIBA 11/2013
1	Antihypertensive Agents (Antihypertensives)IBA 11/2013
1	Glucose (Dextrose)FDA LinkGeneric 11/2013
1	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 10/2013
1	indacaterolIBA 05/2013
1	Adrenergic Receptors (Adrenergic Receptor)IBA 05/2013

Therapy/Procedure

8	Therapeutics 01/2022 - 08/2002
7	Liver Transplantation 10/2021 - 08/2005
1	Drug Therapy (Chemotherapy) 01/2016